Fechete, R. (2009). Data models, graph analysis, and information retrieval from biological data [Diploma Thesis, Technische Universität Wien]. reposiTUm. https://resolver.obvsg.at/urn:nbn:at:at-ubtuw:1-25993
systems biology; omics; biological data; graphs; databases; shortest paths
en
Abstract:
This thesis introduces a possible approach to information extraction from a biological context, by building a molecular dependency network.<br />Our aim is to optimize hypothesis generation for laboratory experiments, with the ultimate goal of disease-associated biomarker and drug target discovery.<br />We present a three-stage method involving data warehousing, scientific information consolidation and analysis. Further, we investigate the method by running tests using specific datasets from B-cell lymphoma and renal transplant ischemia reperfusion injury.