Introduction: The buccal route is a convenient and patient compliant application route.
Aim: This study aimed to evaluate vast range of cellulose based patches. Methods: Patches were manufactured with solvent evaporation method. Patches were characterized in terms of thickness, weight, pH, stickiness and transparency. Furthermore, mucoadhesion was evaluated on buccal porcine mucosa via two assays rotating cylinder and tensile strength assay.
Results: The findings showed uniformity in weight and thickness according to the preparation method. Mucoadhesion assay revealed an 8.13-fold improvement in the total work of adhesion in presence of F1 compared to F10 and F4 exhibited a 2.14-fold enhancement in the maximum detachment force compared to F5. The stability results indicated 6.74-fold for F1 and 5.0-fold for F4 in comparison to F2. Furthermore, methylene blue assay evaluating the mucoprotective properties convinced with continuously protective results for all formulations on the mucosa during an incubation time of 120 min.
Conclusion: Taken together, findings indicated the following ranking for F1> F4> F9 in terms of mucoadhesiveness and stability. In conclusion, cellulose based patches exhibited great and promising potential for various buccal applications and intraoral cavity disorders.