Cotton fabrics show the tendency to wrinkle. Various chemical agents have been used to convey crease-resistance to cellulosic material in an attempt to replace the formaldehyde-releasing crosslinking agent DMDHEU. A novel non-formaldehyde organic-inorganic hybrid material synthesized via the sol-gel route is investigated. The hydrolyzed trialkoxysilane (3-triethoxysilylpropyl)succinic anhydride was reacted with 2,4,6-triamine-1,3,5-triazine (melamine, MEL) at elevated temperature. The as-prepared aqueous solutions were applied to cotton fabrics, which were cured at 160 °C and 220 °C. The physicomechanical data: dry crease recovery angle (DCRA), flexural rigidity, whiteness index (WI), water retention, water vapor permeability were evaluated. An increase in the DCRA can be observed. However, the thermal treatment results in a reduction of the WI. Fourier transform infrared spectroscopy spectra confirm the formation of an imide group. X-ray powder diffraction analysis makes evident that the crystallinity index increased. SEM images make evident that depositions can be observed on the surface.